Bill New's (1999) thoughtful paper has performed the valuable service of clarifying the meaning and the policy implications of paternalism. His careful formulation delimits the domain of justified state paternalism. Having argued successfully, in our view, for a narrow ambit, New proceeds to identify situations that justify paternalism. This comment is written in the spirit of a friendly reformulation that refines and improves the specification of when paternalism is justified. Our argument is two-fold. First, we argue that New's formulation, properly (...) understood, will not readily permit the paternalistic interventions he argues are justified. Second, we identify a class of potentially justified interventions that have paternalistic aspects, but which are neither strictly paternalistic nor market-failure remedies. (shrink)

Critics of commodification object to sales but not gifts of some goods, such as human blood or human organs, on grounds that such trade wrongly coerces, morally corrupts, and crowds out altruism. This essay takes issues with each of these claims. It disputes Micheal Sandel’s claim that voluntary exchange coerces, arguing that he confuses what is unfair with what is unfree. It argues, where trade does create moral costs, that these costs should be weighed against the moral costs of trade (...) bans, such as the loss of human life, and the harms endemic to illegal markets. The essay also quarrels with Richard Titmuss’s The Gift Relationship, arguing that compensation for blood need not crowd out blood donation, that compensation does not preclude a charitable impulse, and that some important gift relationship posses elements of altruism and exchange.Ceux qui critiquent la marchandisation sont contre la vente mais pas contre le don de certains biens comme le sang ou les organes humains parce qu’un tel commerce exercerait une contrainte, corromprait morallement, et ne laisserait pas de place à l’altruisme. Ce papier traite de chacune de ces affirmations. Il consteste l’affirmation de Micheal Sandel selon laquelle l’échange volontaire exerce une contrainte, en suggérant qu’il confond ce qui injuste avec ce qui n’est pas libre. Si le commerce entraîne des coûts moraux, cet essai suggère que ces coûts devraient être comparés avec les coûts moraux associés aux interdictions de commerce tels que la perte de la vie humaine et ceux associés aux maux endémiques des marchés illégaux. Il critique aussi l’ouvrage de Richard Titmuss, “The Gift Relationship” en suggérant que les compensations monétaires en échange d’un don de sang n’évincent pas nécessairement le don de sang, qu’elles n’empêchent pas les impulsions charitables, et que d’importants actes de don comportent des éléments d’altruisme et d’échange. (shrink)

In the bracket mushroom, Schizophyllum commune, a recessive genetic alteration, mnd, causes abnormally hyperplastic three‐dimensional mounds of hyphae to rise from the surface of both haploid and dikaryotic mycelia. mnd, although not a genetic block in the fruiting body developmental pathway, is at least partially epistatic to fruiting. Within dikaryons containing both mutant and wild‐type nuclei, [mnd + mnd+], a nonreciprocal somatic recombination event can lead to stable conversion of the mnd+ region of the wild‐type nucleus to mnd. This transformation (...) to the homoallelic [mnd + mnd] condition involves no genomic areas other than the mnd region and permanently prevents any further fruiting. Studies relating to the recombination mechanism have ruled out a diploid intermediate state and other concomitants of orthodox somatic recombination, as well as whole chromosome transfer. Instead, a novel form of internuclear genetic transfer is postulated whereby a nearby locus, mob+, controls the mobilization of the mnd chromosomal region alone from one nucleus to the other within the binucleate cells of dikaryotic mycelia. (shrink)

Coiled‐coils are found in proteins throughout all three kingdoms of life. Coiled‐coil domains of some proteins are almost invariant in sequence and length, betraying a structural and functional role for amino acids along the entire length of the coiled‐coil. Other coiled‐coils are divergent in sequence, but conserved in length, thereby functioning as molecular spacers. In this capacity, coiled‐coil proteins influence the architecture of organelles such as centrioles and the Golgi, as well as permit the tethering of transport vesicles. Specialized coiled‐coils, (...) such as those found in motor proteins, are capable of propagating conformational changes along their length that regulate cargo binding and motor processivity. Coiled‐coil domains have also been identified in enzymes, where they function as molecular rulers, positioning catalytic activities at fixed distances. Finally, while coiled‐coils have been extensively discussed for their potential to nucleate and scaffold large macromolecular complexes, structural evidence to substantiate this claim is relatively scarce. (shrink)

The recent discovery and structure determination of a novel ubiquitin‐like dimerization domain in protein kinase D (PKD) has significant implications for its activation. PKD is a serine/threonine kinase activated by the lipid second messenger diacylglycerol (DAG). It is an essential and highly conserved protein that is implicated in plasma membrane directed trafficking processes from the trans‐Golgi network. However, many open questions surround its mechanism of activation, its localization, and its role in the biogenesis of cargo transport carriers. In reviewing this (...) field, the focus is primarily on the mechanisms that control the activation of PKD at precise locations in the cell. In light of the new structural findings, the understanding of the mechanisms underlying PKD activation is critically evaluated, with particular emphasis on the role of dimerization in PKD autophosphorylation, and the provenance and recognition of the DAG that activates PKD. (shrink)

Transmissible cancers are elusive and understudied parasitic life forms caused by malignant clonal cells (nine lineages are known so far). They emerge by completing sequential steps that include breaking cell cooperation, evade anti‐cancer defences and shedding cells to infect new hosts. Transmissible cancers impair host fitness, and their importance as selective force is likely largely underestimated. It is, therefore, crucial to determine how common they might be in the wild. Here, we draw a parallel between the steps required for a (...) transmissible cancer to emerge and the steps required for an intelligent civilisation to emerge in the Milky Way using a modified Drake equation. Using numerical analyses, we estimate the potential number of extant marine and bivalve species in which transmissible cancers might exist. Our results suggest that transmissible cancers are more common than expected, and that new lineages can be found by screening a large number of species. (shrink)

: New genetic technologies continue to emerge that allow us to control the genetic endowment of future children. Increasingly the claim is made that it is morally "irresponsible" for parents to fail to use such technologies when they know their possible children are at risk for a serious genetic disorder. We believe such charges are often unwarranted. Our goal in this article is to offer a careful conceptual analysis of the language of irresponsibility in an effort to encourage more care (...) in its use. Two of our more important sub-claims are: A fair judgment of genetic irresponsibility necessarily requires a thick background description of the specific reproductive choice; and there is no necessary connection between an act's being morally wrong and its being irresponsible. These are distinct judgments requiring distinct justifications. (shrink)

This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be (...) preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

People with a repressive coping style are highly motivated to defend themselves against self-concept threats. But what kinds of unfavourable personal characteristics are they most focused on avoiding? Weinberger (Citation1990) suggested that repressors are primarily concerned with seeing themselves (and having others see them) as calm, unemotional people who are not prone to experiencing negative affect. A content analysis of the actual (self-ascribed) and undesired attributes of 349 male and female college students, however, provided no support for that hypothesis. Instead, (...) relative to other participants, repressors’ undesired selves consisted more of traits exemplifying disagreeableness (as defined by the five-factor model). Repressors might not engage in affective self-regulation for its own sake, but because it allows them to control expression of traits with which they are more directly concerned. (shrink)

Insects use path integration (PI) to maintain a home vector, but can also store and recall vector-memories that take them from home to a food location, and even allow them to take novel shortcuts between food locations. The neural circuit of the Central Complex (a brain area that receives compass and optic flow information) forms a plausible substrate for these behaviours. A recent model, grounded in neurophysiological and neuroanatomical data, can account for PI during outbound exploratory routes and the control (...) of steering to return home. Here, we show that minor, hypothetical but neurally plausible, extensions of this model can additionally explain how insects could store and recall PI vectors to follow food-ward paths, take shortcuts, search at the feeder and re-calibrate their vector-memories with experience. In addition, a simple assumption about how one of multiple vector-memories might be chosen at any point in time can produce the development and maintenance of efficient routes between multiple locations, as observed in bees. The central complex circuitry is therefore well-suited to allow for a rich vector-based navigational repertoire. (shrink)

Over the course of the last four decades, William Leon McBride has distinguished himself as one of the most esteemed and accomplished philosophers of his generation. This volume—which celebrates the occasion of his seventy-fifth birthday—includes contributions from colleagues, friends, and formers students and pays tribute to McBride’s considerable achievements as a teacher, mentor, and scholar.

Biological evolution provides a creative fount of complex and subtle adaptations, often surprising the scientists who discover them. However, because evolution is an algorithmic process that transcends the substrate in which it occurs, evolution’s creativity is not limited to nature. Indeed, many researchers in the field of digital evolution have observed their evolving algorithms and organisms subverting their intentions, exposing unrecognized bugs in their code, producing unexpected adaptations, or exhibiting outcomes uncannily convergent with ones in nature. Such stories routinely reveal (...) creativity by evolution in these digital worlds, but they rarely fit into the standard scientific narrative. Instead they are often treated as mere obstacles to be overcome, rather than results that warrant study in their own right. The stories themselves are traded among researchers through oral tradition, but that mode of information transmission is inefficient and prone to error and outright loss. Moreover, the fact that these stories tend to be shared only among practitioners means that many natural scientists do not realize how interesting and lifelike digital organisms are and how natural their evolution can be. To our knowledge, no collection of such anecdotes has been published before. This paper is the crowd-sourced product of researchers in the fields of artificial life and evolutionary computation who have provided first-hand accounts of such cases. It thus serves as a written, fact-checked collection of scientifically important and even entertaining stories. In doing so we also present here substantial evidence that the existence and importance of evolutionary surprises extends beyond the natural world, and may indeed be a universal property of all complex evolving systems. (shrink)

The great richness of the work of Louis Bouyer is well known. In his first publications, Bouyer initiates a return to the sources of the liturgy, the Word and the Fathers. Very characteristically of this movement is Le mystère pascal (1945), which rehabilitates theologically many profound views more or less forgotten. Nevertheless, we also find that, in this work, the author, after opening new avenues, comes to close them. The status Bouyer gives to Holy Saturday manifests this lack of consistency. (...) The present article attempts to explain this situation. At the end, Bouyer’s own approach appears to be a link between the theologies of Thomas Aquinas and Hans Urs von Balthasar. (shrink)

Previous research addressing the association between leisure and happiness has given rise to the hypothesis that informal social activities might contribute more to happiness than solitary activities. In the current study, we tested how the two types of leisure—social and solitary—contribute to a person’s subjective sense of well-being. For the empirical estimate, we used four consecutive quarters of data collected from 533 people over the age of 16, from 13 Tsimane’ hunter-farmer villages in the Bolivian Amazon. Results suggest that only (...) social, not solitary, leisure has a positive and statistically significant association with subjective well-being. The association between solitary leisure and subjective well-being was negligible or negative. Future research should focus on emic definitions of social and solitary time, for solitary time might not always be equivalent to leisure and productive group activities might substitute for social leisure. (shrink)

Growing evidence suggests mothers invest more in girls than boys and fathers more in boys than girls. We develop a hypothesis that predicts preference for girls by the parent facing more resource constraints and preference for boys by the parent facing less constraint. We test the hypothesis with panel data from the Tsimane’, a foraging-farming society in the Bolivian Amazon. Tsimane’ mothers face more resource constraints than fathers. As predicted, mother’s wealth protected girl’s BMI, but father’s wealth had weak effects (...) on boy’s BMI. Numerous tests yielded robust results, including those that controlled for fixed effects of child and household. (shrink)

La reception du christianisme byzantin par l'Eglise catholique presente une sorte d'anomalie. Invoquant l'autorite de Thomas d'Aquin, les theologiens occidentaux rejettent generalement l'idee d'une distinction reelle entre l'essence et les energies divines, tout comme la notion de grace increee, laquelle joue un role essentiel dans la vision de Gregoire Palamas (XIVe siecle). D'un autre cote, ces memes theologiens ont ete nombreux a redecouvrir, durant la periode recente, la pensee de Maxime le Confesseur (VIIe siecle), voyant en celui-ci un genial (...) precurseur de Thomas d'Aquin. Or que resterait-il de la doctrine de Gregoire Palamas sans le patronage de Maxime le Confesseur? Comment meconnaitre l'un et reconnaitre l'autre au nom du meme Thomas d'Aquin? Ce qui vient ici au jour a travers l'etude des contextes et des enjeux doctrinaux, c'est la coexistence, jusqu'alors insoupconnee, de deux representations distinctes du rapport entre le cree et l'incree. L'Occident latin et l'Orient byzantin n'en finissent pas de comprendre differemment cette foi qui leur est pourtant indiscutablement commune. (shrink)

On trouvera ici la présentation et l’édition de deux brèves questions de l’Ermite de saint Augustin, Jacques de Viterbe. Dans la première question, Jacques s’attache à montrer en quel sens il est légitime de dire que les habitus moraux sont innés. Dans la seconde question, il défend la thèse que les habitus des principes moraux appartiennent de façon plus intime à l’âme que les habitus intellectuels. Comme le Viterbien oppose sa position à celle de Thomas d’Aquin, on tente dans (...) la dernière partie de l’article de cerner les raisons philosophiques du désaccord entre les deux auteurs. (shrink)

Résumé — Alors que, pour Thomas d’Aquin et Gilles de Rome, Dieu peut ajouter à la création une série infinie d’espèces de perfection croissante sans compromettre sa transcendance et sans contrevenir aux lois de la logique, Henri de Gand et Godefroid de Fontaines développent des arguments puissants contre cette même idée, arguant notamment que la production d’une telle série impliquerait une infinité en acte d’idées en Dieu. L’article montre comment, dans son Quodlibet I, q. 2 où il expose et (...) critique systématiquement les arguments de Godefroid et d’Henri, Jacques de Viterbe renoue avec une position proche de celle de Thomas et Gilles.— While Thomas Aquinas and Giles of Rome believed that God could produce an infinite number of increasingly more perfect creatures without threatening his transcendence or breaching the laws of logic, Henry of Ghent and Godfrey of Fontaines argued against that belief, holding that such an ability on God’s part would entail the existence of an actual infinity of ideas in the divine intellect. One author who was to be influenced by Henry’s arguments was Godfrey of Fontaines whose views James of Viterbo refutes in Quodlibet I, q. 2. The article examines the detail of James’s arguments against Godfrey and in favor of the view, much like Thomas’ and Giles’, that God can add to the total amount of perfection in creation. (shrink)

The author’s purpose is to understand the role divine ideas play as causal principles in Aquinas’s philosophy. His contention is that, although Thomas’s doctrine of ideas is perhaps not the key to an understanding of his metaphysics, it is certainly “ a key to such an understanding” .The book is divided into six chapters. The first chapter seeks to provide a general definition of divine ideas according to Aquinas. Divine ideas are exemplar causes in the likeness of which God (...) produces creatures. Ideas in the strict sense belong to God’s practical or actually practical knowledge. The causality exercised by exemplars is that of formal causality, but because they are productive of things, they entail efficient and final causality, as well. In chapter 2, Doolan examines Thomas’s arguments in favor of the existence of divine ideas. Chapter 3 deals with the question of the multiplicity of divine ideas. Doolan first establishes, against Gilson and others, that Aquinas did indeed hold that there was a multiplicity of divine ideas. He then shows how Aquinas was able to reconcile the diversity of ideas with God’s simplicity. The gist of the solution involves viewing ideas as nonbeings relative to God, who is, of course, ipsum esse. Now the only way non-beings can enter into God is in. (shrink)

Thomas Aquinas was first and foremost a Christian theologian. Yet he was also one of the greatest philosophers of the Middle Ages. Drawing on classical authors, and incorporating ideas from Jewish and Arab sources, he came to offer a rounded and lasting account of the origin of the universe and of the things to be found within it, especially human beings.